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Generic extended-release venlafaxine
Hi. this article says that generic extended-release venlafaxine will not be available in the US until 2010, but I'm looking at my wife's prescription right now and it's generic extended-release venlafaxine (at least that's what it says) and it's July 2009. Did something change in regulations? A lawsuit perhaps? Could someone change this to reflect the new reality? Thanks!70.105.73.44 (talk) 03:51, 7 July 2009 (UTC)
EDIT to Generic extended-release venlafaxine
After doing some more research I now realize that what my wife has been prescribed as equivalent to Effexor-XR (venlafaxine-ER) is not AB-rated to Effexor-XR . If someone could consider a way to make this clear to the layman that would be directed here by a search engine as he looks for answers, I think that would be great. I was studying the subject because my wife, although on the same dose of venlafaxine-ER as she was Effexor-XR, is having similar side effects to those she would experience if she missed a dose.
Something worth looking in to. We'll have to call the doctor. Anyway. Thanks for pointing me in the right direction! —Preceding unsigned comment added by 70.105.73.44 (talk) 04:22, 7 July 2009 (UTC)
Reality of this drug
i haven't been to this article for some time, but glad to see that the reality of the risks of this drug have been put here with the preponderance of studies. The first part of the article doesn't reflect this adequately.63.250.127.245 (talk) 01:54, 28 January 2009 (UTC) I have added a comment about the black box warnings as the opening statement is badly misleading and prejudiced to make it seem as if this drug is wonderful and without risk. That is not only disingenous but it is misleading. I suggest that my edit be left in place and if anyhone objects to this, please submit for editorial review. This is a FACT and though i have not put a citation, i am sure all editors know that this is beyond question or argument. it is a FACT.... I found a new website that lists items about SSRI and SSRN's in relation to reported side effects and events in which the group of drugs were named or the specific drug was named .. this has more than a thousand entries.. each which is linked to the actual item for review by readers. this is not a statistical study, but is a factual list of actual articles in media about the drugs...ssristories.com i am not posting this in the references by i do suggest that active editors review this.. as i think it deserves to be in this article about this drug and this group of drugs. I am sure at some point, researchers are going to look at these events as more than coincidental.. There was another mass murder in New York State.. i remember when i was a university student that outrage at the Texas Tower massacre, but we seem to have these events happening with a much greater frequency, and it is not a wild stretch to reflect on whether these drugs are the cause.. 67.208.18.54 (talk) 19:16, 5 April 2009 (UTC)
Statement on contraindication in children and adolescents
The statement that venalfaxine is countraindicated in children and adolescents is not supported by either the references or the data. This is a major error.
I am pretty sure that the black box warnings for this drug do have these contraindications. I believe that was one of the main thrusts of the changes to the usage of this drug and a main point of the black box warnings. I suggest you read the actual script on the Wyeth site. Szimonsays (talk) 05:32, 7 June 2008 (UTC)
Adverse Effects
This section needs to be revised.People editing this article seem to have no understanding on how adverse events are reported and later published. Some of the "rare" adverse events reported for venlafaxine are; menopause, rheumatoid arthritis, cellulitis, tendon rupture and breast enlargement, if one is to mention any of the rare adverse events I feel they need to put it in context.I think it's reasonable to assume that most of these "rare" events are not caused by the medication.Secondly, this article in particular emphasizes the adverse events of this drug and puts undue weight on them.Perhaps mentioning the common adverse events(>5% of treated patients and occurs at twice the rate compared to placebo) would suffice ? --Tdonner 12:27, 7 December 2006 (UTC)
i added a reference for the mao/serotonine syndrome problem and did minor editing.---89.60.228.151 (talk) 22:36, 24 February 2008 (UTC)
Withdrawal effects
I see another deletion/dilution of the information on the Effexor Petition which is the most exhaustive documentation of the side effects including withdrawal of this drug. If you don't like the composition, edit and revise, but stop deleting this. It is highly relevant to this entry on Wikipedia. People have a right to have knowledge of this that is not minimized or washed down.
- Yeah, there is no difference between "brain attempting to reach neurochemical stability" and "addiction." People simply don't want to take something that is physically addictive so the companies get creative in their wording. see physical dependency. I vote this be changed to reflect that it is in fact, physically addictive.
I agree with these comments. Some of the editors are constantly deleting any reference to this drug being "addictive" and only leaving in Wyeth research both in vitro and animal studies with rather limited application to the actual experience of patients using Effexor. This is supported by some rather narrow perception of what "addiction" means. As this is not a drug compendium and the definition of the term "addiction" is clearly subject to some argument and interpretation, the term "addiction" clearly belongs in the encyclopedic entry for Effexor and is supported by THOUSANDS of users, as well as a number of recognized authorities - the distinction between "physical dependency" and "addiction" is rather a blurred area. One could make distinctions between the impact of addiction on illicit drugs and that of effexor, but clearly patitents who are put on this drug without being advised of serious adverse effects, nor of withdrawal symptoms and are then faced with trying to get off the drug, describe this as being "hooked", "addicted", and "dependent". Leaving this out of the section on physical and psychological dependency is simply ridiculous beyond reason or ethics. Those are are doing this.. STOP..... if you want to argue the issue or provide useful edits that retain clarity, then do so, but stop this nonsense of removing material that is absolutely relevant to this entry.
any experience with these drugs?
At medium dosages, venlafaxine blocks the reuptake of norepinephrine as well as serotonin. At about 225 mg/day, venlafaxine blocks the reuptake of serotonin and norepinephrine
Are these two sentences saying the same thing? Ubermonkey 22:33, 22 September 2005 (UTC)
- Yes. I rephrased the paragraph so as to be more understandable. ZZYZX 09:25, 8 October 2005 (UTC)
I've been under the impression that one of the common reasons for discontinuation of Venlafaxine in women is anorgasma, caused by delay in the sexual response system. Perhaps this should be listed under common side effects. -Cameron Van Sant 9:11, 12 November 2005 (UTC)
Severe discontinuation symptoms
I have commented out this sentence which has to go unless someone comes up with a Wyeth reference for severe discontinuation syndrome:
Please note that this not about the existence of these symptoms but about Wyeth's calling them a "severe discontinuation syndrome". The worst thing I could find in Wyeth's online documentation was: "While these events are generally self-limiting, there have been reports of serious discontinuation symptoms" (see Effexor info for healthcare professionals (USA only)). AvB ÷ 13:30, 21 January 2006 (UTC)
Discontinuation of this medication sucks. I get the brain shivers even after missing one dose.--K8TEK 23:12, 20 April 2006 (UTC)
(First time writing so if this is useless then please delete as appropriate. If I miss just one dose I get a dizzy head-spinning type sensation and feel nauseous. Also I find Myself edgy and unable to stand any slightly uncomfortable situation. This is with or without a knowledge of my missed dose. Gem-Ra! (talk) 00:04, 5 November 2008 (UTC)
The withdrawal syndrome is fairly well documented, and large numbers of anecdotal reports indicate that it is more common with Venlaf
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